In the winter of 1492, Venice is a city of immense wealth and lethal secrets. Isabella Rossi, a brilliant apprentice apothecary, finds her quiet life shattered when her master is brutally murdered. Entrusted with a cryptic ledger and a vial of an unknown, deadly compound, Isabella is thrust into a sprawling conspiracy to assassinate the Doge and surrender the Venetian Republic to a foreign armada. Hunted by an elite ring of mercenaries known as the Obsidian Council, Isabella must use her knowledge of poisons, ciphers, and the hidden catacombs of the city to stop the plot. With the help of a rogue Murano glassblower, she races against the tolling bells of midnight during the height of Carnivale to save her city from drowning in blood and fire.